In this study, we propose the use of persistent homology – specifically Betti curves for brain age prediction and for distinguishing between healthy and pathological aging. The proposed framework is applied to 100 structural MRI scans from the publicly available ADNI dataset. Our results indicate that Betti curve features, particularly those from dimension-1 (connected components) and dimension-2 (1D holes), effectively capture structural brain alterations associated with aging. Furthermore, cli...