We implement Genetic Algorithms for triangulations of four-dimensional reflexive polytopes which induce Calabi-Yau threefold hypersurfaces via Batyrev's construction. We demonstrate that such algorithms efficiently optimize physical observables such as axion decay constants or axion-photon couplings in string theory compactifications. For our implementation, we choose a parameterization of triangulations that yields homotopy inequivalent Calabi-Yau threefolds by extending fine, regular triangula...