Foundation Models for AI-Enabled Biological Design
Asher Moldwin and Amarda Shehu
本文调查了人工智能生物设计的基础模型,重点关注将大规模、自我监督模型应用于蛋白质工程、小分子设计和基因组序列设计等任务的最新发展。 虽然这个领域正在迅速发展,但这项调查提出并讨论了当前模型和方法的分类。 重点是在适应这些模型用于生物应用的挑战和解决方案,包括生物序列建模架构,生成中的可控性和多模态集成。 该调查结束时讨论了开放性问题和未来方向,为改善生物序列生成的质量提供了具体的下一步。
This paper surveys foundation models for AI-enabled biological design, focusing on recent developments in applying large-scale, self-supervised models to tasks such as protein engineering, small molecule design, and genomic sequence design. Though this domain is evolving rapidly, this survey presents and discusses a taxonomy of current models and methods. The focus is on challenges and solutions in adapting these models for biological applications, including biological sequence modeling architec...